Within this context, since the number of cases was statistically inadequate, lymph node metastases in early-stage endometrial cancer are much less frequent, so this is one of the most important issues that limits our study

Within this context, since the number of cases was statistically inadequate, lymph node metastases in early-stage endometrial cancer are much less frequent, so this is one of the most important issues that limits our study. From your perspective of the learning curve, because of the low incidence of cervical and vulvar cancer, the surgeons experience seems to be difficult to improve. obtained. Medical procedures was made after injection for an average of 5 minutes due to the physiological spread of the blue dye. Then, the standard protocol of hysterectomy was performed and the retroperitoneum was opened to perform lymphadenectomy. The presence of lymph node regions, and presence of a sentinel node was recorded around the trial record form. Positive staining nodes were sent separately for pathological examination. In the course of the study due to insufficient rate of staining, the technique has been changed to cervical and multiple uterine injections. == Results == As the primary end result, an SLN positivity rate of 23% in 6 patients with a total of 8 lymph nodes were found. Cilengitide The amazing obtaining was that in the first technique, the rate was 1/16 (6%), while the second technique, 5/10 (50%), respectively. The difference is usually statistically significant (p=0.001). In endometrial malignancy stage I and II, secondary outcomes for sensitivity, specificity, positive predictive value, negative predictive value were 23%, 0%, 100%, 43%, respectively. Because there E.coli polyclonal to His Tag.Posi Tag is a 45 kDa recombinant protein expressed in E.coli. It contains five different Tags as shown in the figure. It is bacterial lysate supplied in reducing SDS-PAGE loading buffer. It is intended for use as a positive control in western blot experiments were no metastatic lymph nodes found, Cilengitide false negative rate was 0%. == Conclusion == SLN approach is not useful enough to eliminate the need for lymphadenectomy. On the other hand, it facilitates scanning micrometastases and ultrastaging, while its clinical value has not yet been established. However, according to the recent pilot studies, it provides a means for assessing micrometastases for the medium-risk group for local recurrence. Keywords:Sentinel lymph node, endometrium malignancy, surgical staging == zet == == Ama == Sentinel lenf nodu tekniinin endometriyum kanserinde uygulanabilirli ini lmek. == Gere ve Yntemler == Prospektif non-randomize vaka kontrol al-mas olarak, 20102011 yllar arasnda stanbul niversitesi stanbul Tp Fakltesi, Kadn Hastalklar ve Doum Anabilim Dal, Jinekolojik Onkoloji servisinde yaplan preoperatif deerlendirmesi endometriyum kanseri saptanan 26 olgu almaya alnd. alma iin hastalardan aydnlatlm onam formlar ile etik kurul onay alnd. Birincil sonu olarak sentinel lenf nodu (SLN) saptanma oran, sekonder sonu olarak da yalanc negatiflik bata olmak zere duyarllk, zgllk, pozitif ve negatif prediktif deerlerin saptanmas belirlendi. SLN tekni- i olarak periton ykant sitolojisini takiben uterus fundusta subserozal myometriyuma 5 cc injektr ile metilen mavisi verildi. Boya verilmesini takiben ortalama 5 dakika cerrahiye ara verilerek boya maddenin yaylmas beklendi. Broad ligaman ve tubalar klempe edilerek tmr hcrelerinin mobilizasyonunun engellenmesi amaland. Ardndan standart Cilengitide histerektomi protokol uyguland. Retroperitoneum alarak lenfadenektomi yapld. alma formuna, karlan lenf nodu blgeleri ve varsa sentinel nodu varl kaydedildi. Pozitif boyanma gsteren lenf nodlarnn patolojik incelemeye ayrca gnderilmesi ngrld. almann seyrinde boyanma oran yetersiz grld iin servikal ve multipl uterus injeksiyonu tekniine geildi. == Bulgular == Primer sonu olan SLN pozitiflii 6 hastada toplam 8 lenf nodu ile %23 orannda bulunmutur. lk teknikte oran 1/16 (%6) iken ikinci teknikte Cilengitide 5/10 (%50) olarak bulunmutur. Aradaki fark istatistiksel olarak anlamldr (p=0.001). Sekonder sonular olarak evre I ve II endometriyum kanserinde SLN tekniinin duyarll %23, zgll %0, pozitif prediktif deeri %100, negatif prediktif deeri %43 olarak bulunmutur. Yalanc negatiflik deeri de pozitif lenf nodu bulunmad ndan %0da kalmtr. == Sonu == SLN yaklam lenfadenektomi ihtiyacn bertaraf edecek kadar deerli olmamakla birlikte rutin pratikte tm lenf nodlarna uygulaman n mmkn grnmedii ve tedavi ynetiminde oturmu bir yeri olmayan ancak pilot almalarda elde edilen verilere gre nks iin orta risk grubu kabul edilen mikrometastaz incelemesine imkan vererek ultrastaging ans yaratmaktadr. == Introduction == Endometrial malignancy is the most common gynecologic malignancy in developed countries and its incidence has been increasing (1,2). Although the data has poor reliability, according to Turkish Health Statistics 2006 reports; the incidence of endometrium malignancy is usually 0.0029, which is the second most common gyenocologic cancer. Surgical staging of endometrial malignancy.