Emerg Infect Dis [serial around the Internet]

Emerg Infect Dis [serial around the Internet]. windows *Acute respiratory symptoms were rhinorrhea, cough, sore throat, or dyspnea. br / ?Influenza-like illness?was defined as a temperature 38.0C in conjunction with any of the following: rhinorrhea, cough, sore throat, or dyspnea. Table 2 Avian influenza computer virus A (H5N1) neutralizing antibody titers among study participants (N = 901), as determined by microneutralization assay, Thailand, 2005 thead th rowspan=”2″ valign=”bottom” align=”left” scope=”col” colspan=”1″ Village /th th rowspan=”2″ valign=”bottom” align=”center” scope=”col” colspan=”1″ No. residents /th th valign=”bottom” colspan=”7″ align=”center” scope=”colgroup” rowspan=”1″ No. residents by antibody titer hr / /th th valign=”bottom” colspan=”1″ CID 755673 align=”center” scope=”colgroup” rowspan=”1″ 5 /th th valign=”bottom” align=”center” scope=”col” rowspan=”1″ colspan=”1″ 5 /th th valign=”bottom” align=”center” scope=”col” rowspan=”1″ colspan=”1″ 10 /th th valign=”bottom” align=”center” scope=”col” rowspan=”1″ colspan=”1″ 20 /th th valign=”bottom” align=”center” scope=”col” rowspan=”1″ colspan=”1″ 40 /th th valign=”bottom” align=”center” scope=”col” rowspan=”1″ colspan=”1″ 80 /th th valign=”bottom” align=”center” scope=”col” rowspan=”1″ colspan=”1″ 80 /th /thead A228227100000B204202200000C209202601*000D hr / 260 hr / 257 hr / 2 hr / 1? hr / 0 hr / 0 hr / 0 hr / 0 hr / Total9018881111000 Open in a separate windows *Serum obtained from a 52-year-old woman (farmer) in village C without history of respiratory symptoms who reported contact with a sick/lifeless poultry and live poultry. br / ?Serum obtained from an 18-year-old man in CID 755673 village D without history of respiratory symptoms who also reported contact with a sick/dead poultry and live poultry. Conversation Participants in this study were from villages in central and northern Thailand where common, confirmed outbreaks of influenza (H5N1) contamination in poultry and at least 1 human influenza (H5N1) case experienced occurred during 2004. A substantial DUSP5 proportion of participants reported exposure to yard poultry, including contact with sick or lifeless chickens, the primary risk factor for influenza (H5N1) contamination ( em 8 /em , em 9 /em ). Nevertheless, we found no serologic evidence of moderate or subclinical influenza (H5N1) contamination, suggesting that clade 1 influenza computer virus A (H5N1) strains circulating in Thailand among yard poultry during 2004 did not transmit easily to our study population. Our findings differ from those from a study of poultry workers in Hong Kong, among whom the estimated seroprevalence of influenza computer virus (H5N1) neutralizing antibodies was 10% during the 1997 outbreak ( em 10 /em ). The Hong Kong poultry workers, however, likely had much greater intensity of exposure to poultry infected with influenza computer virus (H5N1) than our study population experienced. Furthermore, the clade 1 influenza computer virus (H5N1) strains that infected poultry and humans in Thailand during 2004 were antigenically and genetically unique from your clade 0 influenza computer virus (H5N1) strains that caused the 1997 outbreak in Hong Kong ( em 11 /em ). Our obtaining of CID 755673 no serologic evidence of asymptomatic or moderate influenza (H5N1) contamination among Thai villagers is usually consistent with findings from smaller influenza computer virus (H5N1) seroprevalence studies among workers in live poultry markets in the Peoples CID 755673 Republic of China ( em 12 /em ), among villagers exposed to yard poultry infected with clade 1 influenza computer virus (H5N1) in rural Cambodia ( em 13 /em ), among poultry workers exposed to poultry infected with clade 2.2 influenza computer virus (H5N1) in northern Nigeria ( em 14 /em ), and among poultry farmers exposed to poultry infected with clade 1 influenza computer virus (H5N1) in Thailand ( em 7 /em ). Results of studies conducted since 2004 thus suggest that the risk for influenza (H5N1) contamination is usually low among persons exposed to infected poultry; however, our obtaining of no serologic evidence of asymptomatic or moderate influenza (H5N1) contamination among CID 755673 Thai villagers suggests that the high case-fatality proportion in Thailand (17 deaths among 25 persons with confirmed contamination) may accurately reflect the severity of the contamination in Thailand. Our study had 3 notable limitations. First, because study participants, most of whom were enrolled by convenience sampling, were generally older than the populations of the villages in which.