Although its physiological significance is not completely understood, much attention to its effects on psychological activities has been recently paid by scholars (Iwatsubo were associated with major depression, SSRIs may alter the pathologic signal transduction pathway via the regulation of G protein, might influence the neurobiological effect of SSRIs

Although its physiological significance is not completely understood, much attention to its effects on psychological activities has been recently paid by scholars (Iwatsubo were associated with major depression, SSRIs may alter the pathologic signal transduction pathway via the regulation of G protein, might influence the neurobiological effect of SSRIs. MDD. It showed that the patients with rs5443TT and rs2230739GG have a relatively good efficacy in response to short-term SSRIs. We also found that good efficacy appeared in depressed patients with rs2230739GG in response to long-term SSRIs. It suggested that different genotypes of rs5443 and rs2230739 might influence the signal transduction pathways of second message and affect therapeutic efficacy. Introduction Depressive disorder is a common psychiatric disease, afflicting 3%C5% of the population worldwide. The etiologic foundations remain unknown, although decades of research on neurobiochemistry, neuropathology, and psychopharmacology have made great progress. Family, twin, and adoption studies on depression have provided evidence for the involvement of genetic factors, suggesting that heritable factors play an important role in the etiology of depression (Wender (McMahon (Mato (Lee (Gould and Manji, 2002; Hines and Tabakoff, 2005; Hines 825C/T (rs5443) (Wilkie 825C/T (rs5443) was related with depression. Compared with those who did not carry a T allelic gene (rs5443), the depression patients who carried a T allelic gene have a better response to SSRIs. The results also suggested that the GG genotype has better efficacy response to short-term and long-term SSRIs than AG, AA of rs2230739. was a subunit recently found. Although its physiological significance is not completely understood, much attention to its effects on psychological activities has been recently paid by scholars (Iwatsubo were associated with major depression, SSRIs may alter the pathologic signal transduction pathway via the regulation of G protein, might influence the neurobiological effect of SSRIs. After the patients with the different genotypes of rs5443 and rs223073 are treated with SSRIs, second messenger transduction pathway may be mediated, leading to an antidepressant effect. Since the transduction process of second messenger is complex in cells, the definitive mechanism needs further study to be confirmed. Long-term follow-up studies showed that 63.2% exhibited recurrent episodes. Only 41.9% of depressed patients had significant efficacy in a 1-year follow-up. It is similar to the study of Demyttenaere em et al /em . (2008). According to optimal scaling, we found that a long-term effect might be related to the polymorphism of rs2230739. The patients with the GG genotype of rs2230739 had a Biochanin A (4-Methylgenistein) good long-term effect. Long-term SSRI treatment may have been expressed via third messenger and CREB (Chen em et al. /em , 2001), which then influenced the repairing function of nerve cells. Further studies are needed to prove CDKN2A whether Biochanin A (4-Methylgenistein) the patients with GG types are much better than others in repairing the function of central nerve cells. However, there were some limitations. First, the sample size is not enough. Second, these SNPs could not represent all genes correlated with 5-HT2A. Therefore, we will enlarge the sample size and further increase the genes to research, and will regard 5-HT2A rs6311C/T polymorphism as a biological endo-phenotype to Biochanin A (4-Methylgenistein) be explored in future. Acknowledgments This work was supported, in part, by a grant from the National Natural Science Fund of China (30900484) and by a grant from the Science Fund of Tianjin Bureau of Public Health (2010KR10). The authors are grateful to all the doctors and nurses who participated in their study for technical assistance. They appreciate all the patients and normal controls in their study. Author Disclosure Statement No competing financial interests exist..